ea0029oc5.5 | Obesity Basic | ICEECE2012
Aizawa-Abe M.
, Ebihara K.
, Ebihara C.
, Kusakabe T.
, Aotani D.
, Gumbili V.
, Mashimo T.
, Serikawa T.
, Nakao K.
Introduction: It is critical to consider species differences in translating the findings of obesity-model animals into human pathophysiology. Leptin plays an important role in regulating energy homeostasis. Although much has been learned from genetically obese leptin deficient Lepob/Lepob mice, some flaws were noted in mice as animal models for human diabetes.Methods: To develop a rat leptin-deficient mod...